There are 2 standard routes on Misti though you might easily invent your own:
1) 3-day, 2-night trek with optional ascent of Misti
2) 2-day, 1-night Misti climb
Most hikers opt for the 2-day climb. Up & down as quickly as possible. Most sign-on with an agency in Arequipa & climb with a guide.
But for hikers we recommend the longer trip with or without guide for the following reasons:
- gets you to the stark, empty backside of Misti
- incline is slightly easier from the back
- lovely hike out on day 3 through unspoiled farms & villages
We were alone on our side of Misti, camping high. It was a unique experience.