Wear comfortable, broken-in footwear. If you feel a hot spot, stop & take off your boots.
Wicking inner socks may help prevent blisters.
Bring Leukoplast or Elastoplast bandages, duct tape & any other blister first aid products you like, just in case.
If you do get a blister, using a sterile needle, prick the blister a few times. Drain without touching the fluid or holes. Seal with liquid Betadine and, when dry, place some tape over it. We usually use duct tape it's inexpensive and seems to stay as well as anything else.
Insect Bites & Stings? Thorns?
No worries. Nothing can live on Misti!
Be sure you are not stuck with cactus needles.